PROFESSIONAL EVENT SPEAKERS
Dr. Parthasarathi DasIIT-ISM Dhanbad, India
Dr. Partha Sarathi Das has been chosen to receive the prestigious CRSI Bronze Medal for his incomparable research contribution in the field of Chemistry by Chemical Research Society of India (CRSI). Dr Das, having his Post-Doctoral degree and experiences from reputed institutions like Harvard University, USA, Tohoku University, Japan and RWTH-Aachen, Germany, started his career as Senior Scientist @ Dr. Reddy’s Laboratories, Hyderabad. He has had more than 10 years of industry experience before joining as Senior Scientist at Integrative Medicine Centre of (CSIR) at Jammu.
Currently, he is serving as Associate Professor in the Department of Applied Chemistry at IIT(ISM) Dhanbad since December, 2017.
His areas of expertise are Catalysis and Heterocyclic Chemistry, Medicinal Chemistry and Drug Discovery, Total Synthesis of Biological Active Molecules, Affordable Synthesis of FDA-Approved Drug, Synthesis and Characterization of Drug Impurities.
Dr. Jaya Shree AnireddyJNTUH, India
Professor of Chemistry & Head of the Department, Centre for Chemical Sciences and Technology, Institute of Science and Technology, Chairman, BOS, CCST, IST, JNTUH. Jawaharlal Nehru Technological University, Hyderabad-500085, Telangana, India.
Dr. Saminathan KayarohanamGeomatika University College, Malaysia
Cluster Dean / Associate Professor Head, Department of Pharmaceutical Education, Geomatika University College, Kuala Lumpur, WP Kuala Lumpur, Malaysia. He received the PhD in Department of Phytochemistry, The Open International University for Complementary Medicines – Srilanka in 2012. He established new drug information centre in Malaysia (GUC).
Major area of interests include Phytochemistry, Pharmaceutical Science and Pharmacy practice
Bioenergy, Environment And Sustainable DevelopmentAbdeen Mustafa Omer, Energy Research Institute, Nottingham NG7 4EU, United Kingdom
Sustainable energy is energy that, in its production or consumption, has minimal negative impacts on human health and the healthy functioning of vital ecological systems, including the global environment. It is an accepted fact that renewable energy is a sustainable form of energy, which has attracted more attention during recent years. A great amount of renewable energy potential, environmental interest, as well as economic consideration of fossil fuel consumption and high emphasis of sustainable development for the future will be needed.
Synthesis and characterization of mono-, bis- and tetrakis-NHC silver(I) complexes and their potential for wound healingDr. Muhammad Adnan Iqbal, University of Agriculture, Pakisthan
New mono-, bis- and tetrakis-NHC silver complexes were synthesized by reaction of Ag2O with respective azolium (benzimidazolium and imidazolium) halide salts [1, 2]. Complexes were characterized by using FTIR and NMR spectroscopic techniques and X-ray crystallography of single crystals. Seven complexes (C1-C7) were selected from each NHC series (mono-, bis- and tetrakis-) and examined their potential for wound healing/contraction. For this 14 day biological examination was done to check in vivo wound contraction potential of synthesized silver complexes. 10 % sample of each treatment was evaluated against negative control (no treatment) and standard Contratobex. Treatments were applied for 14 days twice a day and each day wound contraction was examined. All the complexes showed moderate to very good wound contraction abilities.
Potential was measured in %age wound contraction (%WC). Mono-benzimidazolium complexe (C1) showed the least 53 % WC which was close to negative control (control) with 41.5 % WC. Bis-imidazolium silver complex (C2) showed 72 % WC and Bis-benzimidazolium silver complexes (C3-C6) showed 77-80 % WC. Very high percentage wound contraction potential was exhibited by tetra-benzimidazolium silver complex (C7) with 81.7 % WC which was comparable to standard drug (standard) with 83.7% WC. Results showed that the wound contraction ability of newly synthesized compounds increased with increasing number of silver ions. However the reason behind the highest %WC of standard drug may be the highly sophisticated and optimized conditions are followed during the formulation of drugs which was not fully applied in our lab experiment.
QUINAZOLINE-3(4H)-ONE ANALOGS AS AN IMPORTANT CLASS OF ANALGESIC DRUG DISCOVERYProf.Gopal Natesan Faculty of Pharmacy, MAHSA University
The development of new drugs has been responsible for decreasing human morbidity and mortality more than any other scientific endeavor during our lifetime. In recent years, a large number of pharmacologically important heterocyclic compound have been synthesized and are being widely used as drugs. The heterocyclic containing nitrogen, quinazolinone nucleus exhibit a wide spectrum of biological activities.
Non-steroidal anti-inflammatory drugs (NSAID) are important therapeutic drug category for the treatment of inflammation in addition to analgesic and antipyretic activities. NSAID’s are used for rheumatoid arthritis and other inflammatory diseases starting from Aspirin to the recent selective COX-2 inhibitors. It has evident from the literature that, the anti-inflammatory response of the NSAID is either inhibiting the prostaglandin H synthase or cyclooxygenase (COX) enzyme. However, the chronic use of NSAID’s leads to potential for gastrointestinal bleeding, heart attack or stroke. Due to their suboptimal therapeutic profile, the search for non-opioid analgesics to replace this well-established therapeutics remains a critical pursuit and NSAID’s is also has limitations due to the poor GI tolerance even though it have been widely used clinically. Therefore, investigation of new NSAIDs is still a major challenge and production of safer and more active NSAIDs and analgesic drugs are need.
Quinazolin-4(3H)-ones are potential bioactive agents which are having significant therapeutic effect with substitution at 1st / 2nd / 3rd position of quinazolin-4(3H)-ones. A series of 2,3-disubstituted-4(3H)-quinazolin-4-one derivatives were synthesized by reacting anthranilic acid with substituted benzoyl chloride followed by condensing with hydrazine hydrate. The 3-amino -2-substituted quinazolinone has further subjected to Schiff base with isatin /aliphatic or aromatic aldehyde and mannich products were obtained from the reaction of amines with isatin based Schiff bases. The results of the various study conducted indicates that quinazoline pharmacophore is having vast therapeutic potential, which attracts strong interest to explore in medicinal chemistry for the drug discovery and development.